Bertilsson L
Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Clin Pharmacol Ther. 2007 Nov;82(5):606-9. doi: 10.1038/sj.clpt.6100358. Epub 2007 Sep 26.
Early after the introduction of the classical tricyclic antidepressants and neuroleptics, it was shown that the plasma concentrations of these drugs varied between patients given the same dose. This variation is to a major extent due to the variation in the activity of cytochrome P450 (CYP) enzymes (cf. review by Bertilsson et al.1) During recent year(s), the different CYP enzymes catalyzing the metabolism of these drugs have been identified and the clinical relevance has also been identified. This brief review highlights the clinical importance and ethnic differences in the metabolism of these drugs.
在经典三环类抗抑郁药和抗精神病药引入后不久，就发现给予相同剂量的患者，这些药物的血浆浓度存在差异。这种差异在很大程度上归因于细胞色素P450（CYP）酶活性的变化（参见Bertilsson等人的综述1）。近年来，已经鉴定出催化这些药物代谢的不同CYP酶，并且也确定了其临床相关性。这篇简短的综述强调了这些药物代谢的临床重要性和种族差异。
