Liu Yonghong, Yang Xuhong, Liao Wei, Liu Ling, Yan Bo, Lin Xu, Xi Jing, Xu Hongru, Cheng Huafu, Zhou Dong
Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Aug;24(4):748-51.
Using simultaneous EEG-correlated functional MRI (EEG-fMRI), we studied the blood oxygenation level-dependent (BOLD) signals in a juvenile myoclonic epilepsy (JME) patient with interictal epileptiform discharges. Extensive and symmetric activation and deactivation areas were assessed in bilateral hemispheric regions respectively, and these signals decreased gradually from the parieto-occipital region to the frontal region. Activations were found in cuneus, insulae, mesial midfrontal region, midline and bilateral cerebellum and thalamus, while the deactivities were in the bilateral anterior frontal region and parietal region as well as the posterior cingulate gyri. These findings suggest that the synchronized neuronal activities represented by spike and wave complex in EEG be reflected in the activation of BLOD signals in thalamocortical regions. However, those regions of deactivation reflect the suspension of the default state of brain function resulting indirectly from this discharge. There is good correspondence between neuronal activity (EEG) and fMRI. The combination of EEG and fMRI is a powerful tool in studying brain function.
我们使用同步脑电图相关功能磁共振成像（EEG-fMRI）技术，对一名伴有发作间期癫痫样放电的青少年肌阵挛性癫痫（JME）患者的血氧水平依赖（BOLD）信号进行了研究。分别在双侧半球区域评估了广泛且对称的激活和失活区域，这些信号从顶枕区到额叶逐渐减弱。在楔叶、岛叶、额中内侧区域、中线以及双侧小脑和丘脑发现了激活，而失活则出现在双侧前额叶区域、顶叶区域以及后扣带回。这些发现表明，脑电图中棘波和慢波复合波所代表的同步神经元活动在丘脑皮质区域的BOLD信号激活中得到反映。然而，那些失活区域反映了这种放电间接导致的脑功能默认状态的暂停。神经元活动（脑电图）与功能磁共振成像之间存在良好的对应关系。脑电图和功能磁共振成像的结合是研究脑功能的有力工具。
