Jonas Jost B, Witzens-Harig Mathias, Arseniev Lubomir, Ho Anthony D
Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University, Heidelberg, Germany.
Acta Ophthalmol. 2008 Mar;86(2):225-6. doi: 10.1111/j.1600-0420.2007.00987.x. Epub 2007 Sep 26.
To report on the feasibility and safety of an intravitreal injection of mononuclear cells derived from autologous bone marrow.
A 43-year-old patient with very advanced atrophy of the retina and optic nerve caused by diabetic retinopathy had undergone pars plana vitrectomy with silicone oil endotamponade. Despite complete retinal attachment, vision was limited to defective light perception as a result of retinal capillary occlusion. As an ultima ratio, the patient underwent an intravitreal injection of autologous bone marrow-derived stem cells obtained by isolating mononuclear cells from 100 ml of bone marrow.
On postoperative day 1, a cluster of injected cells was observed on the retinal surface in the inferior fundus periphery. The anterior chamber was completely filled with silicone oil, which was released transcorneally. Subsequently, intraocular pressure remained normal and the anterior chamber was free of inflammatory cells or flare. Within 1 week of the injection, visual acuity remained at light perception. There were no signs of any side-effects of the therapy, such as inflammation or infection.
Intravitreal autologous bone marrow mononuclear cell transplantation is technically feasible.
报告玻璃体腔内注射自体骨髓来源的单核细胞的可行性和安全性。
一名43岁因糖尿病性视网膜病变导致视网膜和视神经严重萎缩的患者接受了玻璃体切除联合硅油内填充术。尽管视网膜完全复位，但由于视网膜毛细血管闭塞，视力仅为光感缺陷。作为最后的手段，该患者接受了玻璃体腔内注射自体骨髓来源的干细胞，这些干细胞是通过从100毫升骨髓中分离单核细胞获得的。
术后第1天，在眼底下方周边视网膜表面观察到一簇注射的细胞。前房完全充满硅油，通过角膜释放。随后，眼压保持正常，前房无炎性细胞或闪光。注射后1周内，视力仍为光感。没有该治疗的任何副作用迹象，如炎症或感染。
玻璃体腔内自体骨髓单核细胞移植在技术上是可行的。
