Liu Zhan, Jiao Qingfang, Xu Jianguo, Wang Xiang, Li Sanzhong, You Chao
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, PR China.
Surg Neurol. 2008 Mar;69(3):253-60; discussion 260. doi: 10.1016/j.surneu.2007.02.019. Epub 2007 Sep 27.
Spontaneous spinal epidural hematoma is a rare but disabling disease. To explore its characters and find out what factors influence the prognosis, we gave a retrospective analysis of 23 patients in our department in the past 8 years.
Spontaneous spinal epidural hematoma was diagnosed by taking MRIs of patients without surgical management or by histopathological examination. We registered patient's case history, laboratory examination, radiological image, treatment, pathological result, and prognosis after 3 months and gave them nonparameter analysis.
Primary neurological status and progressive intervals have correlation with prognosis (P< .01), and the latter less than 12 hours predict worse prognosis (P= .032). Spinal edema in MRI predicts pessimistic prognosis (P= .013). Long hematoma predicts worse prognosis (P= .02). Preoperative interval, emphasized by other authors, has no statistical correlation with prognosis in this study (P= .832). Finally, patients with a single hematoma or hematoma mingled with other spinal disturbance have the same prognosis (P= .065).
The primary neurological status, progressive interval, spinal edema, and size of hematoma will influence the prognosis of the patient with SSEH. The major treatment is surgical intervention, and it should be operated as soon as possible to avoid the aggravation of neurological status. Conservative treatment is not considered unless patient's neurological deficiency has relieved in the early period.
自发性脊髓硬膜外血肿是一种罕见但致残的疾病。为探讨其特征并找出影响预后的因素,我们对过去8年里我科收治的23例患者进行了回顾性分析。
通过对未接受手术治疗患者进行磁共振成像(MRI)检查或组织病理学检查来诊断自发性脊髓硬膜外血肿。我们记录患者的病史、实验室检查、影像学图像、治疗情况、病理结果以及3个月后的预后情况,并对其进行非参数分析。
初始神经状态和病情进展间隔与预后相关(P<0.01),病情进展间隔小于12小时提示预后较差(P=0.032)。MRI显示的脊髓水肿提示预后不佳(P=0.013)。血肿范围大提示预后较差(P=0.02)。本研究中,其他作者所强调的术前间隔时间与预后无统计学相关性(P=0.832)。最后,单一血肿或血肿合并其他脊髓病变的患者预后相同(P=0.065)。
初始神经状态、病情进展间隔、脊髓水肿及血肿大小会影响自发性脊髓硬膜外血肿患者的预后。主要治疗方法为手术干预,应尽早手术以避免神经状态恶化。除非患者早期神经功能缺损已缓解,否则不考虑保守治疗。