通过筛选生产酵母乙醇脱氢酶同工酶

Production of yeast alcohol dehydrogenase isoenzymes by selection.

作者信息

Wills C

出版信息

Nature. 1976 May 6;261(5555):26-9. doi: 10.1038/261026a0.

Abstract

Mutants of yeast alcohol dehydrogenase have been produced that protect the cell against the poisonous aldehyde acrolein by increasing the NADH-NAD ratio. The altered properties include changes both in binding constants and in cooperativity. Such mutants may be useful in exploring the nature of adaptation at the molecular level.

摘要

已培育出酵母乙醇脱氢酶突变体，其通过提高NADH-NAD比率来保护细胞免受有毒醛丙烯醛的侵害。这些改变的特性包括结合常数和协同性的变化。此类突变体可能有助于在分子水平上探索适应性的本质。