Yamauchi Y, Yamanouchi I
Department of Pediatrics, Children's Medical Center, Okayama National Hospital, Japan.
Biol Neonate. 1991;60(5):314-9. doi: 10.1159/000243423.
We demonstrated the phenomenon of transiently increasing total serum bilirubin within 4 h of phototherapy. We attempted to resolve the mechanism of this phenomenon in 29 hyperbilirubinemic full-term newborn infants who received continuous phototherapy for 24 h. Our present study suggests that this phenomenon may in part be bilirubin load (photobilirubin, photoisomers) from skin and subcutaneous bilirubin and/or peripheral capillary wall bilirubin into the blood stream pool, rather than delayed clearance of bilirubin and photoisomers from the blood stream to bile or urine. Further study is needed to determine these bilirubin compounds for safe and more effective phototherapy.
我们证实了光疗4小时内血清总胆红素短暂升高的现象。我们试图在29名接受24小时持续光疗的高胆红素血症足月儿中解析这一现象的机制。我们目前的研究表明，这种现象可能部分是由于皮肤和皮下胆红素以及/或外周毛细血管壁胆红素中的胆红素负荷（光胆红素、光异构体）进入血流池，而非胆红素和光异构体从血流到胆汁或尿液的清除延迟。需要进一步研究以确定这些胆红素化合物，从而实现安全且更有效的光疗。
