Contassot Emmanuel, Gaide Olivier, French Lars E
Department of Dermatology, Zurich University Hospital, Gloriastrasse 31, 8091 Zürich, Switzerland.
Dermatol Clin. 2007 Oct;25(4):487-501, vii. doi: 10.1016/j.det.2007.06.010.
Interactions between death receptors from the tumor necrosis factor superfamily and their ligands play a crucial role in the development and the integrity of the epidermis. The major consequence resulting from death receptor targeting is apoptosis. Evidence for dysregulation of death receptor signaling associated with the pathogenesis of selected cutaneous diseases, including toxic epidermal necrolysis, graft versus host disease, and skin cancer, are reviewed herein.
肿瘤坏死因子超家族的死亡受体与其配体之间的相互作用在表皮的发育和完整性中起着至关重要的作用。靶向死亡受体的主要后果是细胞凋亡。本文综述了与某些皮肤疾病（包括中毒性表皮坏死松解症、移植物抗宿主病和皮肤癌）发病机制相关的死亡受体信号传导失调的证据。
