[蔓越莓（大果越桔）与尿路感染：研究模型及文献综述]

[Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature].

作者信息

Lavigne J-P, Bourg G, Botto H, Sotto A

机构信息

Institut national de la santé et de la recherche médicale, ESPRI 26, université de Montpellier-I, UFR de médecine, avenue Kennedy, CS83021, 30908 Nîmes cedex 02, France.

出版信息

Pathol Biol (Paris). 2007 Nov;55(8-9):460-4. doi: 10.1016/j.patbio.2007.07.005. Epub 2007 Oct 1.

DOI:10.1016/j.patbio.2007.07.005

PMID:17905535

Abstract

Cranberries (Vaccinium macrocarpon) have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Among cranberry compounds, a group of proanthocyanidins (PACs) with A-type linkages were isolated which exhibit bacterial anti-adhesion activity against uropathogenic Escherichia coli strains. These PAC inhibit P-fimbriae synthesis and induce a bacterial deformation. This activity was demonstrated on both antibiotic susceptible and resistant bacteria. This review focused on the last discoveries in the knowledge of cranberry effects.

摘要

蔓越莓（大果越桔）长期以来因其在预防尿路感染方面的有益作用而备受关注。在蔓越莓化合物中，分离出了一组具有A型连接的原花青素（PACs），它们对尿路致病性大肠杆菌菌株具有细菌抗粘附活性。这些PAC抑制P菌毛的合成并诱导细菌变形。这种活性在抗生素敏感和耐药细菌中均得到证实。本综述聚焦于蔓越莓作用相关知识的最新发现。