Howell Amy B
Marucci Center or Blueberry and Cranberry Research and Extension, Rutgers, The State University of New Jersey, Chatsworth, NJ 08019, USA.
Mol Nutr Food Res. 2007 Jun;51(6):732-7. doi: 10.1002/mnfr.200700038.
Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed.
长期以来，食用蔓越莓（大果越桔）与预防尿路感染有关。从历史上看，其有益机制被认为是由于果酸在尿液中产生抑菌作用。然而，最近从蔓越莓中分离出了一组具有A型连接的原花青素（PACs），它们对尿路致病性P菌毛大肠杆菌的抗生素敏感和耐药菌株均表现出细菌抗粘附活性。本文综述了食用蔓越莓与维持尿路健康之间的联系，以及A型连接的蔓越莓PACs的结构多样性、药代动力学、定量分析和细菌抗粘附生物活性。
