白细胞介素15在小鼠伤口愈合和黏膜感染中的调节作用。

A regulatory role of interleukin 15 in wound healing and mucosal infection in mice.

作者信息

Kagimoto Yoshiko, Yamada Hisakata, Ishikawa Takahiro, Maeda Naoyoshi, Goshima Fumi, Nishiyama Yukihiro, Furue Masutaka, Yoshikai Yasunobu

机构信息

Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

J Leukoc Biol. 2008 Jan;83(1):165-72. doi: 10.1189/jlb.0307137. Epub 2007 Sep 28.

DOI:10.1189/jlb.0307137

PMID:17906118

Abstract

IL-15 plays a critical role in the development and maturation of gammadelta intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-beta1 upon TCR triggering than in control mice. In vivo neutralization of TGF-beta ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-beta1, promoting wound healing but impeding protection against genital HSV-2 infection.

摘要

白细胞介素-15（IL-15）在γδ上皮内T淋巴细胞（IEL）的发育和成熟过程中发挥关键作用，已知IEL在小鼠伤口愈合和炎症消退中起重要作用。在本研究中，我们发现，在MHC I类启动子控制下的IL-15转基因（Tg）小鼠表现出加速的伤口愈合，但对单纯疱疹病毒2型（HSV-2）的生殖器感染高度敏感。与对照小鼠相比，IL-15 Tg小鼠皮肤和生殖器官中的IEL在TCR触发后产生异常高水平的转化生长因子-β1（TGF-β1）。体内中和TGF-β可改善IL-15 Tg小鼠对生殖器HSV-2感染的易感性。综上所述，IL-15的过表达可能刺激IEL产生TGF-β1，促进伤口愈合，但阻碍对生殖器HSV-2感染的防护。