新生儿自然杀伤细胞功能：与抗病毒免疫防御的相关性。
Neonatal natural killer cell function: relevance to antiviral immune defense.
作者信息
Lee Yen-Chang, Lin Syh-Jae
机构信息
Department of Obstetrics/Gynecology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
出版信息
Clin Dev Immunol. 2013;2013:427696. doi: 10.1155/2013/427696. Epub 2013 Aug 26.
Abstract
Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and their clinical implications.
摘要
与成年人相比，新生儿特别容易受到各种病原体的影响，这部分归因于他们不成熟的先天免疫和适应性免疫。自然杀伤细胞在无需预先致敏的情况下，对病毒感染细胞提供一线先天免疫反应。本综述更新了新生儿细胞与其成年对应细胞相比的表型和功能缺陷及其临床意义。
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