离子对氧氟沙星和头孢曲松抗菌活性的影响。
The effects of ions on antibacterial activity of ofloxacin and ceftriaxone.
作者信息
Gürdal H, Usanmaz S, Tulunay F C
机构信息
Department of Pharmacology, Faculty of Medicine, University of Ankara, Turkey.
出版信息
Chemotherapy. 1991;37(4):251-5. doi: 10.1159/000238863.
MIC and MBC values of ofloxacin and ceftriaxone were investigated against Staphylococcus aureus in MHB and MHB containing additional Mg2+, Al3+, Fe3+, Ca2+, Zn2+, Cu2+. The addition of Mg2+, Al3+, Fe3+ increased the MIC and MBC of ofloxacin and the MBC of ceftriaxone. However, the addition of these cations did not change the MIC of ceftriaxone. Our findings suggest that these interactions might be due to the formation of chelates between metal ions and antibiotics. These results also indicate that some cations may have an important role in the antibacterial activity of antibiotics.
在MHB以及含有额外Mg2+、Al3+、Fe3+、Ca2+、Zn2+、Cu2+的MHB中，研究了氧氟沙星和头孢曲松对金黄色葡萄球菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。添加Mg2+、Al3+、Fe3+会增加氧氟沙星的MIC和MBC以及头孢曲松的MBC。然而，添加这些阳离子不会改变头孢曲松的MIC。我们的研究结果表明，这些相互作用可能是由于金属离子与抗生素之间形成了螯合物。这些结果还表明，一些阳离子可能在抗生素的抗菌活性中起重要作用。
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