Randjelovic Tomislav, Filipovic Branka, Babic Darko, Cemerikic Vesna, Filipovic Branislav
Department of Gastroenterohepatology, Clinical and Hospital Center Bezanijska Kosa, Belgrade 11080, Serbia.
World J Gastroenterol. 2007 Nov 7;13(41):5533-6. doi: 10.3748/wjg.v13.i41.5533.
Carcinosarcomas are rare, malignant, biphasic tumors. We report the case of a 62-year-old man with gastric carcinosarcoma, along with its clinical, macroscopic and histopathological features. Macroscopically, a specimen of deformed stomach was obtained that measured 200 mm x 150 mm x 100 mm. A 150 mm x 100 mm x 50 mm exophytic tumoral mass (Borrmann type I) was found, which involved the posterior wall from the cardia to the antrum. Histopathologically, a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia, with interposed fascicles of fusiform atypical cells and numerous large, rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18, epithelial membrane antigen, carcinoembryonic antigen, chromogranin A and vimentin. Liver metastases were diagnosed 8 mo postoperatively, and the patient died 4 mo later. A review of the available literature is also presented.
癌肉瘤是一种罕见的恶性双相肿瘤。我们报告一例62岁男性胃癌肉瘤病例，及其临床、大体和组织病理学特征。大体上，获取了一个变形胃标本，尺寸为200 mm×150 mm×100 mm。发现一个150 mm×100 mm×50 mm的外生性肿瘤块（Borrmann I型），累及从贲门至胃窦的后壁。组织病理学显示为混合型恶性肿瘤：伴有肠化生的腺癌，其间夹杂梭形非典型细胞束以及众多大的圆形和椭圆形细胞。肿瘤细胞角蛋白18、上皮膜抗原、癌胚抗原、嗜铬粒蛋白A和波形蛋白的组织化学染色呈阳性。术后8个月诊断出肝转移，患者4个月后死亡。同时还对现有文献进行了综述。
