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原发性椎管内癌肉瘤综合治疗1例报告

A case report of comprehensive treatment for primary intraspinal carcinosarcoma.

作者信息

Yan Chang, Zhang Chao-Jun, Wei Jun-Bao, Liang Hui-Wen, Qu Song

机构信息

Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.

Department of Pathology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.

出版信息

Front Oncol. 2025 Jan 7;14:1479193. doi: 10.3389/fonc.2024.1479193. eCollection 2024.

Abstract

BACKGROUND

Carcinosarcoma is a rare and highly aggressive biphasic malignant tumor. To date, no cases of primary intraspinal carcinosarcoma have been reported.

CASE PRESENTATION

This study reports a case of a 36-year-old female with primary intra dural extramedullary carcinosarcoma. The patient underwent surgery at initial diagnosis, followed by two courses of radiotherapy due to residual tumor, as part of a comprehensive antitumor treatment. Despite good tumor control, she ultimately died of respiratory failure.

DISCUSSION

This is the first reported case of primary intra dural extramedullary carcinosarcoma, detailing its imaging characteristics, pathological morphology, and treatment process. The tumor was responsive to radiotherapy. The rapid progression of intraspinal carcinosarcoma suggests it may be underdiagnosed or underreported, highlighting the need for more cases for clinical evaluation and treatment strategies.

摘要

背景

癌肉瘤是一种罕见且具有高度侵袭性的双相恶性肿瘤。迄今为止,尚无原发性椎管内癌肉瘤的病例报道。

病例介绍

本研究报告了一例36岁女性原发性硬脊膜内髓外癌肉瘤患者。患者在初诊时接受了手术,由于残留肿瘤随后进行了两个疗程的放疗,作为综合抗肿瘤治疗的一部分。尽管肿瘤得到了良好控制,但她最终死于呼吸衰竭。

讨论

这是首例报道的原发性硬脊膜内髓外癌肉瘤病例,详细描述了其影像学特征、病理形态及治疗过程。该肿瘤对放疗有反应。椎管内癌肉瘤的快速进展表明其可能存在诊断不足或报告不足的情况,凸显了需要更多病例进行临床评估和制定治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba47/11747408/8660362fce1d/fonc-14-1479193-g001.jpg

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