Benson Amanda C, Torode Margaret E, Singh Maria A Fiatarone
The School of Exercise & Sport Science, Faculty of Health Sciences, University of Sydney, Sydney, Australia.
Int J Pediatr Obes. 2006;1(4):222-31. doi: 10.1080/17477160600962864.
To investigate the relationship of muscular strength and cardiorespiratory fitness (CRF) to insulin resistance.
In a cross sectional study of 126 volunteers (10-15 years) we measured insulin, glucose, lipids, body mass, height, waist circumference (WC), strength and CRF. Linear and logistic regression models assessed the relationships between these factors and estimated insulin resistance (Homeostasis Assessment Model2; HOMA2-IR).
Greater insulin resistance was associated with greater adiposity, lower CRF, and strength. Upper body strength and WC were the only independent predictors of insulin resistance, accounting for 39% of the variance (p < 0.001). Children in the highest and middle tertiles of absolute upper body strength were 98% less likely to have high insulin resistance than those with the lowest strength, adjusted for maturation and central adiposity, body mass (OR = 0.019; p = 0.003). Similar trends were present for high vs. low CRF.
Muscular strength has been identified for the first time as an independent and powerful predictor of better insulin sensitivity in children. Lower strength, CRF and higher central adiposity are highly predictive of higher levels of insulin resistance in this cohort, and should be considered potential targets for interventions designed to enhance metabolic fitness in children and adolescents.
研究肌肉力量和心肺适能（CRF）与胰岛素抵抗之间的关系。
在一项对126名志愿者（10 - 15岁）的横断面研究中，我们测量了胰岛素、葡萄糖、血脂、体重、身高、腰围（WC）、力量和CRF。线性和逻辑回归模型评估了这些因素与估计的胰岛素抵抗（稳态评估模型2；HOMA2 - IR）之间的关系。
更高的胰岛素抵抗与更高的肥胖程度、更低的CRF和力量相关。上肢力量和WC是胰岛素抵抗的唯一独立预测因素，解释了39%的方差（p < 0.001）。在根据成熟度、中心性肥胖、体重进行调整后，绝对上肢力量处于最高和中间三分位数的儿童发生高胰岛素抵抗的可能性比力量最低的儿童低98%（比值比 = 0.019；p = 0.003）。高CRF与低CRF之间也存在类似趋势。
首次确定肌肉力量是儿童胰岛素敏感性更好的独立且有力的预测因素。在该队列中，较低的力量、CRF以及较高的中心性肥胖高度预示着更高水平的胰岛素抵抗，应被视为旨在增强儿童和青少年代谢适能的干预措施的潜在目标。
