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[结直肠癌指南对临床实践的影响]

[Effect of the guidelines for colorectal cancer on clinical practice].

作者信息

Watanabe Masahiko

机构信息

Department of Surgery, School of Medicine, Kitasato University, Sagamihara, Japan.

出版信息

Nihon Geka Gakkai Zasshi. 2007 Sep;108(5):259-62.

Abstract

The guidelines for the management of colorectal cancer set out standard treatment policies for this type of cancer. The guidelines were released more than a year ago and have already been so widely adopted that they are used in daily practice by approximately 90% of physicians engaged in the treatment of colorectal cancer. The detailed descriptions related to early cancer in the guidelines are practical, but also tend to standardize various unnecessary surgical treatments. The extent of bowel resection and lymph node dissection is stipulated in detail, but the scientific basis for these requirements needs to be clarified. In addition, because of constant advances in chemotherapy, there should be specific descriptions of the standard therapy available at the present time, and participation in clinical trials should be encouraged. Although there is no standard method of surveillance, the guideline policies are very helpful under the present circumstances. However, there is a need to explore more rational surveillance that take into account cost effectiveness, QOL, and radiation exposure among other factors. The guidelines are a treatment menu that do not cover individualized medical practice, and new treatments cannot be devised by always adhering to the menu.

摘要

结直肠癌管理指南规定了这类癌症的标准治疗策略。这些指南在一年多以前发布,并且已经被广泛采用,以至于大约90%从事结直肠癌治疗的医生在日常实践中都在使用。指南中与早期癌症相关的详细描述很实用,但也倾向于使各种不必要的手术治疗标准化。肠道切除和淋巴结清扫的范围有详细规定,但这些要求的科学依据需要阐明。此外,由于化疗不断取得进展,应该对当前可用的标准疗法进行具体描述,并鼓励参与临床试验。虽然没有标准的监测方法,但在当前情况下,指南政策非常有帮助。然而,有必要探索更合理的监测方法,同时考虑成本效益、生活质量和辐射暴露等因素。这些指南是一份治疗菜单,并不涵盖个体化医疗实践,而且总是遵循这份菜单无法设计出新的治疗方法。

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