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癌症疼痛中脊髓上段和脑干的经皮毁损性疼痛治疗:CT引导技术、适应证及结果

Percutaneous destructive pain procedures on the upper spinal cord and brain stem in cancer pain: CT-guided techniques, indications and results.

作者信息

Kanpolat Y

机构信息

Department of Neurosurgery, School of Medicine, Ankara University, Ankara, Turkey.

出版信息

Adv Tech Stand Neurosurg. 2007;32:147-73. doi: 10.1007/978-3-211-47423-5_6.

Abstract

In the century of science and technology, the average life span has increased, bringing with it an increase in the incidence of degenerative and cancer disease. Intractable pain is usually the main symptom of cancer. With the advancement in technology, there is a large group of patients with intractable pain problems who can benefit from special help medically or surgically. Destructive pain procedures are necessary to control the cancer pain and are based on the lesioning of the pain conducting pathways. Percutaneous cordotomy, trigeminal tractotomy and extralemniscal myelotomy are special methods based on lesioning of the pain conducting pathways. The procedure consists of obtaining direct morphological appearance of the upper spinal cord and surrounding structures by computed tomography (CT). The next step is functional evaluation of the target and its environment by impedance measurement and stimulation. The final step is terminated with controlled lesioning obtained by a radiofrequency system (generator, needles, electrode system). In the last two decades, CT-guided destructive procedures were used as minimally invasive procedures as follows: percutaneous cordotomy (207 patients), trigeminal tractotomy-nucleotomy (65 patients), and extralemniscal myelotomy (16 patients). Most of these patients had cancer pain. Minimally invasive CT-guided destructive pain procedures are still safe and effective operations for relieving intractable cancer pain in selected cases.

摘要

在科技的世纪里,平均寿命有所延长,随之而来的是退行性疾病和癌症发病率的上升。顽固性疼痛通常是癌症的主要症状。随着技术的进步,有一大群顽固性疼痛问题患者能够从医学或外科的特殊帮助中受益。破坏性疼痛治疗方法对于控制癌症疼痛是必要的,且基于对疼痛传导通路的损伤。经皮脊髓切断术、三叉神经束切断术和脊髓外髓切断术是基于对疼痛传导通路损伤的特殊方法。该手术包括通过计算机断层扫描(CT)获得上脊髓及其周围结构的直接形态外观。下一步是通过阻抗测量和刺激对目标及其周围环境进行功能评估。最后一步是通过射频系统(发生器、针、电极系统)进行可控损伤来完成。在过去二十年中,CT引导下的破坏性手术作为微创手术被用于以下方面:经皮脊髓切断术(207例患者)、三叉神经束切断术 - 核切断术(65例患者)和脊髓外髓切断术(16例患者)。这些患者大多数患有癌症疼痛。对于特定病例,CT引导下的微创破坏性疼痛手术仍是缓解顽固性癌症疼痛的安全有效的手术。

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