Fiocchi Maria F, Moretti Antonio J, Powers John M, Rives Terry
Department of Periodontics, University of Texas Dental Branch, Houston, USA.
Am J Dent. 2007 Aug;20(4):217-20.
To compare the effectiveness of an agent that promotes deposition of amorphous calcium phosphate (Quell Desensitizer) to a commonly used product, sodium fluoride solution (Nupro Neutral), in the reduction of root sensitivity after periodontal therapy, in a prospective, convenient sample, double-blind clinical trial.
Thirty patients were enrolled and treated, resulting in 40 teeth treated with the test product and 40 teeth treated with the control product. The clinical parameters tested at baseline and in the follow-up visits (1, 2, and 4 weeks after treatment) were the following: plaque index, gingival index, gingival recession, and response to mechanical and cold stimulation with airblast and ice. Patients were also asked to report the grade of pain response on a Visual Analogue Scale (VAS) on the same schedule as the clinical parameters.
Plaque index and gingival index were not significantly different between test and control groups throughout the study. Most recession was observed on midbuccal surfaces. Buccal surfaces evoked higher pain response compared to lingual surfaces. It was concluded that both control and test treatments reduced root sensitivity response reported with mechanical or cold stimulation. No statistically significant differences were observed when the data of both groups were compared by a Student's t-test at the 0.05 level of significance.
在一项前瞻性、便利样本、双盲临床试验中，比较一种促进无定形磷酸钙沉积的制剂（Quell脱敏剂）与一种常用产品氟化钠溶液（Nupro中性）在牙周治疗后降低牙根敏感方面的有效性。
招募并治疗了30名患者，结果用测试产品治疗了40颗牙齿，用对照产品治疗了40颗牙齿。在基线以及随访就诊时（治疗后1周、2周和4周）测试的临床参数如下：菌斑指数、牙龈指数、牙龈退缩以及对用气枪和冰块进行机械和冷刺激的反应。还要求患者按照与临床参数相同的时间表在视觉模拟量表（VAS）上报告疼痛反应等级。
在整个研究过程中，测试组和对照组之间的菌斑指数和牙龈指数没有显著差异。大部分退缩出现在颊面中部。与舌面相比，颊面引起的疼痛反应更高。得出的结论是，对照治疗和测试治疗均降低了机械或冷刺激报告的牙根敏感反应。当两组数据在0.05的显著性水平上通过学生t检验进行比较时，未观察到统计学上的显著差异。
