阿仑膦酸盐治疗后牙釉质溶解
Dental enamel dissolution after alendronate treatment.
作者信息
Gandolfi Maria G, Nucci Cesare, Prati Carlo, Mongiorgi Romano
机构信息
Center of Biomineralogy, Crystallography and Biomaterials, San Donato, Italy.
出版信息
Am J Dent. 2007 Aug;20(4):235-40.
PURPOSE
To evaluate the effect of treatment with a bisphosphonate (alendronate) on human dental enamel dissolution in vitro.
METHODS
The dissolution of each enamel sample was evaluated by monitoring the calcium release in 0.1M lactic acid solution at pH 4.5 (acidic solution) during dissolution tests, after topical alendronate treatment with 0.1M alendronate solutions at pH 5.0, pH 7.4 and pH 9.0.
RESULTS
Data showed that alendronate treatment, both at pH 5.0 and pH 7.4, obtained a statistically significant reduction of enamel demineralization during dissolution test reaction time (45 minutes). The protective effect was not present after treatment at pH 9.
目的
评估双膦酸盐（阿仑膦酸盐）治疗对人牙釉质体外溶解的影响。
方法
在用pH值为5.0、pH值为7.4和pH值为9.0的0.1M阿仑膦酸盐溶液进行局部阿仑膦酸盐治疗后，通过监测溶解试验期间在pH值为4.5的0.1M乳酸溶液（酸性溶液）中的钙释放来评估每个牙釉质样品的溶解情况。
结果
数据显示，在pH值为5.0和pH值为7.4时进行阿仑膦酸盐治疗，在溶解试验反应时间（45分钟）内牙釉质脱矿质有统计学意义的显著减少。在pH值为9时治疗后不存在保护作用。
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