使用稳态评估（HOMA）模型评估土耳其性早熟女童的胰岛素抵抗情况。

Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model.

作者信息

Evliyaoğlu Olcay, Berberoğlu Merih, Adiyaman Pelin, Aycan Zehra, Ocal Gönül

机构信息

Department of Pediatric Endocrinology, Ankara University, Faculty of Medicine, Ankara, Turkey.

出版信息

Turk J Pediatr. 2007 Apr-Jun;49(2):165-70.

PMID:17907516

Abstract

Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche.

摘要

青春期阴毛早现可能是良性的，也可能是一些女孩胰岛素抵抗的早期标志。本研究的目的是使用间接胰岛素抵抗参数，评估青春期前出现青春期阴毛早现的女孩（n = 19；平均年龄 = 6.93 +/- 1.78）与年龄和坦纳分期匹配的对照组（n = 10；平均年龄 = 7.55 +/- 1.32）的胰岛素抵抗情况。通过口服葡萄糖耐量试验（OGTT）、间接胰岛素抵抗（IR）参数[稳态评估（HOMA）模型：HOMA-IR、葡萄糖/胰岛素（G/I）]和血清脂质谱对两组进行比较。青春期阴毛早现的女孩，其平均基线胰岛素水平和HOMA-IR值显著高于对照组，G/I比值低于对照组。根据HOMA-IR值和G/I比值，胰岛素抵抗的发生率分别为42.1%和31.6%。即使在诊断时，很大一部分青春期阴毛早现的女孩胰岛素抵抗也有所增加。