Ogawa Rei, Oki Koichiro, Hyakusoku Hike
Nippon Medical School, Department of Plastic and Reconstructive Surgery1, 1-5 Sendagi Bunkyoku, Tokyo 113-8603, Japan.
Regen Med. 2007 Sep;2(5):831-7. doi: 10.2217/17460751.2.5.831.
Vascularized tissue regeneration has a great deal of potential in clinical medicine. Appropriate 3D tissue regeneration that yields tissue with the desired function and shape requires both growth signals and vascularization. In this paper, we discuss vascularized tissue regeneration using various vessel systems: artificial vessel, autologous vascular graft, autologous vascular bundle transfer and tissue engineered vessel. Vascularized 3D tissue regeneration will require a great deal of additional research before it can be applied to clinical situations. Several promising studies of vascularized tissue regeneration have been reported. However, additional studies into the maturation of neovascularization, the development of effective biomaterial, and the possibility of using stem cells will be needed before these techniques can be used in the clinical situation.
血管化组织再生在临床医学中具有巨大潜力。产生具有所需功能和形状的组织的合适三维组织再生既需要生长信号也需要血管化。在本文中，我们讨论了使用各种血管系统进行血管化组织再生的情况：人工血管、自体血管移植物、自体血管束转移和组织工程血管。在血管化三维组织再生能够应用于临床之前，还需要大量的额外研究。已经报道了一些关于血管化组织再生的有前景的研究。然而，在这些技术能够应用于临床之前，还需要对新生血管成熟、有效生物材料的开发以及使用干细胞的可能性进行更多研究。
