霍奇金淋巴瘤描述性、病因学及分子流行病学的新进展。

New aspects in descriptive, etiologic, and molecular epidemiology of Hodgkin's lymphoma.

作者信息

Landgren Ola, Caporaso Neil E

机构信息

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Boulevard, Building EPS/Room 7110, Bethesda, MD 20892-7236, USA.

出版信息

Hematol Oncol Clin North Am. 2007 Oct;21(5):825-40. doi: 10.1016/j.hoc.2007.07.001.

DOI:10.1016/j.hoc.2007.07.001

PMID:17908622

Abstract

Epstein-Barr virus (EBV) has remained the main candidate suggested as the infection causing Hodgkin's lymphoma for several years. However, EBV genome has been found only within the tumor in about 20%-40% of Hodgkin's lymphoma cases with a prior diagnosis of infectious mononucleosis. Recently, autoimmune and related conditions have drawn attention to a potential role for immune-related and inflammatory conditions in the etiology and pathogenesis of the malignancy. Evidence from multiple affected families from case series, a twin study, a case-control study, and population-based registry studies implicate a role for genetic factors. Simultaneously, data from Eastern Asia and among Chinese immigrants in North America indicate increasing incidence trends for Hodgkin's lymphoma being associated with westernization. These results emphasize an interaction between environmental and genetic risk factors in Hodgkin's lymphoma.

摘要

多年来，爱泼斯坦-巴尔病毒（EBV）一直是被认为导致霍奇金淋巴瘤的主要感染源。然而，在先前被诊断为传染性单核细胞增多症的霍奇金淋巴瘤病例中，仅约20%-40%的肿瘤内发现了EBV基因组。最近，自身免疫及相关病症使人们开始关注免疫相关和炎症性病症在该恶性肿瘤病因和发病机制中的潜在作用。来自病例系列研究中的多个患病家族、一项双胞胎研究、一项病例对照研究以及基于人群的登记研究的证据表明遗传因素起到了一定作用。同时，来自东亚以及北美华裔移民的数据表明，霍奇金淋巴瘤发病率上升趋势与西方化有关。这些结果强调了霍奇金淋巴瘤环境风险因素与遗传风险因素之间的相互作用。