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The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat.

作者信息

Langton Julia M, Kim Jee Hyun, Nicholas Jennifer, Richardson Rick

机构信息

School of Psychology, The University of New South Wales, Sydney 2052, Australia.

出版信息

Learn Mem. 2007 Sep 25;14(10):665-8. doi: 10.1101/lm.692407. Print 2007 Oct.

DOI:10.1101/lm.692407
PMID:17909101
Abstract

Recent findings reveal qualitative developmental differences in extinction of learned fear. The present study explored potential developmental differences in the role of NMDA in acquisition and extinction. Rats were injected with MK-801 prior to fear conditioning or extinction training. Acquisition was found to be NMDA dependent in both age groups, whereas extinction was found to be NMDA dependent in 23-day-old rats, but NMDA independent in 16-day-old rats. These results illustrate another fundamental developmental difference in extinction as well as a dissociation in the role of NMDA in the acquisition and extinction of fear early in development.

摘要

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引用本文的文献

[1]
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Mol Neurobiol. 2022-7

[2]
Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets.

Front Hum Neurosci. 2021-8-26

[3]
Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment.

Behav Brain Res. 2021-7-23

[4]
1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia.

Pharmacol Rep. 2021-4

[5]
NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.

Dev Psychobiol. 2019-10-17

[6]
Mechanisms of fear learning and extinction: synaptic plasticity-fear memory connection.

Psychopharmacology (Berl). 2018-11-10

[7]
The impact of maternal separation and isolation stress during stress hyporesponsive period on fear retention and extinction recall memory from 5-week- to 1-year-old rats.

Exp Brain Res. 2019-1

[8]
Reproductive experience alters the involvement of N-methyl-D-aspartate receptors in fear extinction, but not fear conditioning, in female Sprague Dawley rats.

Psychopharmacology (Berl). 2018-6-29

[9]
Elucidating the mechanisms of fear extinction in developing animals: a special case of NMDA receptor-independent extinction in adolescent rats.

Learn Mem. 2018-3-15

[10]
Juvenile female rats, but not male rats, show renewal, reinstatement, and spontaneous recovery following extinction of conditioned fear.

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