一名儿科患者因治疗性注射A型肉毒杆菌毒素导致医源性肉毒中毒。

Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient.

作者信息

Crowner Beth E, Brunstrom Janice E, Racette Brad A

机构信息

Program in Physical Therapy, Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

出版信息

Clin Neuropharmacol. 2007 Sep-Oct;30(5):310-3. doi: 10.1097/WNF.0b013e31804b1a0d.

DOI:10.1097/WNF.0b013e31804b1a0d

PMID:17909312

Abstract

Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

摘要

A型肉毒杆菌毒素常用于减轻脑瘫患儿的痉挛和肌张力障碍。我们报告了一名儿科患者，因注射毒素严重过量（40 U/kg）而发生全身性肉毒中毒。该病例凸显了医生在给儿童注射前充分了解关于A型肉毒杆菌毒素致死剂量50%的灵长类动物和人类文献的重要性。