Godoy G, Taneja S S
Urologic Oncology Program, Department of Urology, New York University Medical Center, New York, NY 10016, USA.
Prostate Cancer Prostatic Dis. 2008;11(1):20-31. doi: 10.1038/sj.pcan.4501014. Epub 2007 Oct 2.
High-grade prostatic intraepithelial neoplasia (HGPIN) is a premalignant lesion associated with increased risk of coexistent cancer or delayed progression to carcinoma. Extended biopsy schemes have improved the ability to rule out concurrent cancers, increased the detection of isolated HGPIN and removed the routine necessity for immediate repeat biopsy. As the natural history of HGPIN is poorly defined, and no non-invasive marker allows monitoring of progression to cancer, routine delayed interval biopsy should be considered in all patients. In this article, we present an overview of the existing literature on HGPIN and a proposed strategy for clinical management.
高级别前列腺上皮内瘤变（HGPIN）是一种癌前病变，与同时存在癌症或延迟进展为癌的风险增加相关。扩展活检方案提高了排除同时存在癌症的能力，增加了孤立性HGPIN的检出率，并消除了立即重复活检的常规必要性。由于HGPIN的自然病史尚不明确，且没有非侵入性标志物可用于监测其向癌症的进展，因此应考虑对所有患者进行常规延迟间隔活检。在本文中，我们概述了关于HGPIN的现有文献，并提出了一种临床管理策略。
