Potent oxindole based human beta3 adrenergic receptor agonists.
作者信息
Stevens F Craig, Bloomquist William E, Borel Anthony G, Cohen Marlene L, Droste Christine A, Heiman Mark L, Kriauciunas Aidas, Sall Daniel J, Tinsley Frank C, Jesudason Cynthia D
机构信息
Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
出版信息
Bioorg Med Chem Lett. 2007 Nov 15;17(22):6270-3. doi: 10.1016/j.bmcl.2007.09.011. Epub 2007 Sep 7.
PMID:17911024
Abstract
The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.
摘要
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