用于检测新生儿和婴儿尿路感染的筛查试验评估。
Evaluation of a screening test for detecting urinary tract infection in newborns and infants.
作者信息
Lejeune B, Baron R, Guillois B, Mayeux D
机构信息
Microbiology and Public Health Laboratory, CHU Morvan, Brest, France.
出版信息
J Clin Pathol. 1991 Dec;44(12):1029-30. doi: 10.1136/jcp.44.12.1029.
The results of a study of a screening test for urinary tract infection (UTI) in infants under 18 months is reported. Two hundred and forty three urine specimens were tested in the laboratory using AMES Multistix 8SG reagent strips read by photometer. The strips included three potential markers for urinary tract infection: leucocyte esterase, nitrite, and protein. The predictive value of a positive result (PPV) was low. The predictive value of negative test (NPV) when combining the screen of leucocyte esterase, nitrite, and protein was 99.4% with no difference between boys and girls. The test for leucocyte esterase had a 97.6% negative predictive value. An examination of the results by age confirms the good NPV in all age groups. Paediatricians should find Multistix 8SG strips a useful aid in the diagnosis of urinary tract infection in infants, and that costly culture of samples with negative strip tests can be avoided.
本文报告了一项针对18个月以下婴儿尿路感染（UTI）筛查试验的研究结果。在实验室中，使用光度计读取AMES Multistix 8SG试剂条对243份尿液样本进行了检测。这些试剂条包含用于尿路感染的三种潜在标志物：白细胞酯酶、亚硝酸盐和蛋白质。阳性结果的预测值（PPV）较低。当联合检测白细胞酯酶、亚硝酸盐和蛋白质时，阴性试验的预测值（NPV）为99.4%，男孩和女孩之间无差异。白细胞酯酶检测的阴性预测值为97.6%。按年龄对结果进行检查证实了所有年龄组的NPV都较好。儿科医生应发现Multistix 8SG试剂条对婴儿尿路感染的诊断很有用，并且可以避免对试剂条检测结果为阴性的样本进行昂贵的培养。
Zotero 插件