Lundmark Frida, Duvefelt Kristina, Hillert Jan
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital - Huddinge, Stockholm, Sweden.
J Neuroimmunol. 2007 Dec;192(1-2):171-3. doi: 10.1016/j.jneuroim.2007.08.015. Epub 2007 Oct 25.
IL7 is a nonredundant cytokine, essential for T cell survival and development in humans. We genotyped nine tagging single nucleotide polymorphisms (SNP), representing all parts of the IL7 gene, in 1,210 Swedish multiple sclerosis (MS) patients and 1,234 healthy controls. None of the SNPs showed a significantly different distribution in MS, and haplotype analysis also failed to reveal differences between patients and controls. We conclude that the IL7 gene is very unlikely to influence the genetic susceptibility to MS in this population.
白细胞介素7是一种不可或缺的细胞因子，对人类T细胞的存活和发育至关重要。我们对1210名瑞典多发性硬化症（MS）患者和1234名健康对照者进行了基因分型，检测了代表白细胞介素7基因所有区域的9个标签单核苷酸多态性（SNP）。这些单核苷酸多态性在MS患者中均未显示出显著不同的分布，单倍型分析也未能揭示患者与对照之间的差异。我们得出结论，在这一人群中，白细胞介素7基因极不可能影响对MS的遗传易感性。
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