de la Hoz Fernando, Perez Ligia, de Neira Marlen, Hall Andrew J
Universidad Nacional de Colombia, Ciudad Universitaria, Cra 30 Cll 45, Edificio 471, Facultad de Medicina, Oficina 150, Bogotá, Colombia.
Int J Infect Dis. 2008 Mar;12(2):183-9. doi: 10.1016/j.ijid.2007.06.010. Epub 2007 Oct 2.
To evaluate the effectiveness of a recombinant hepatitis B vaccine used in endemic areas of Colombia, as well as risk factors associated with hepatitis B virus (HBV) infection and carriage after vaccine introduction.
A cross-sectional study was carried out in urban and rural areas of the Colombian Amazon, a highly endemic area for hepatitis B infection. Children under 12 years of age and their mothers were selected for the study using one-stage cluster sampling (N=2145) and were examined for HBV serological markers and antibodies against surface antigen (anti-HBs).
There has been a reduction of 60-75% in the prevalence of HBV infection and hepatitis B surface antigen (HBsAg) carriage since HBV vaccination was introduced. Receiving the first dose of HBV vaccine at more than two months after birth was one of the factors associated with HBV carrier status. Maternal HBV infection was also associated with infection in the child.
The recombinant Cuban hepatitis B vaccine has contributed to the reduction of the infection in this highly endemic area, though further efforts are required to improve timely vaccination for children at high risk.
评估在哥伦比亚乙肝流行地区使用的重组乙肝疫苗的有效性，以及疫苗引入后与乙肝病毒（HBV）感染和携带相关的危险因素。
在哥伦比亚亚马逊地区的城乡开展了一项横断面研究，该地区是乙肝感染的高流行区。采用单阶段整群抽样法选取12岁以下儿童及其母亲进行研究（N = 2145），检测其HBV血清学标志物及抗表面抗原抗体（抗-HBs）。
自引入乙肝疫苗后，HBV感染率和乙肝表面抗原（HBsAg）携带率降低了60% - 75%。出生后两个多月才接种第一剂乙肝疫苗是与HBV携带者状态相关的因素之一。母亲HBV感染也与儿童感染有关。
古巴重组乙肝疫苗有助于在这个高流行地区减少感染，不过仍需进一步努力改善对高危儿童的及时接种。
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