Chen Yan, Timms Peter, Chen Yi-Ping Phoebe
School of Engineering and Information Technology, Deakin University, Australia.
Biomol Eng. 2007 Dec;24(6):603-8. doi: 10.1016/j.bioeng.2007.08.017. Epub 2007 Aug 19.
Chlamydiae are important pathogens of humans, birds and a wide range of animals. They are a unique group of bacteria, characterized by their developmental cycle. Chlamydia has been difficult to study because of their obligate intracellular growth habit and lack of a genetic transformation system. However, the past 5 years has seen the full genome sequencing of seven strains of Chlamydia and a rapid expansion of genomic, transcriptomic (RT-PCR, microarray) and proteomic analysis of these pathogens. The Chlamydia Interactive Database (CIDB) described here is the first database of its type that holds genomic, RT-PCR, microarray and proteomics data sets that can be cross-queried by researchers for patterns in the data. Combining the data of many research groups into a single database and cross-querying from different perspectives should enhance our understanding of the complex cell biology of these pathogens. The database is available at: http://www3.it.deakin.edu.au:8080/CIDB/.
衣原体是人类、鸟类及多种动物的重要病原体。它们是一类独特的细菌，以其发育周期为特征。由于衣原体专性胞内生长习性以及缺乏遗传转化系统，对其研究一直颇具难度。然而，在过去5年里，已有7株衣原体完成了全基因组测序，并且对这些病原体的基因组学、转录组学（逆转录聚合酶链反应、微阵列）和蛋白质组学分析迅速扩展。这里描述的衣原体交互式数据库（CIDB）是首个此类数据库，它保存了基因组、逆转录聚合酶链反应、微阵列和蛋白质组学数据集，研究人员可以对这些数据集进行交叉查询以寻找数据中的模式。将众多研究小组的数据整合到一个数据库中，并从不同角度进行交叉查询，应该能够增进我们对这些病原体复杂细胞生物学的理解。该数据库可通过以下网址获取：http://www3.it.deakin.edu.au:8080/CIDB/ 。
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