Kolpakov Fedor, Poroikov Vladimir, Sharipov Ruslan, Kondrakhin Yury, Zakharov Alexey, Lagunin Alexey, Milanesi Luciano, Kel Alexander
Institute of Systems Biology, 15, Detskiy proezd, Novosibirsk 630090, Russia.
Nucleic Acids Res. 2007 Jan;35(Database issue):D550-6. doi: 10.1093/nar/gkl912.
Computational modelling of mammalian cell cycle regulation is a challenging task, which requires comprehensive knowledge on many interrelated processes in the cell. We have developed a web-based integrated database on cell cycle regulation in mammals in normal and pathological states (Cyclonet database). It integrates data obtained by 'omics' sciences and chemoinformatics on the basis of systems biology approach. Cyclonet is a specialized resource, which enables researchers working in the field of anticancer drug discovery to analyze the wealth of currently available information in a systematic way. Cyclonet contains information on relevant genes and molecules; diagrams and models of cell cycle regulation and results of their simulation; microarray data on cell cycle and on various types of cancer, information on drug targets and their ligands, as well as extensive bibliography on modelling of cell cycle and cancer-related gene expression data. The Cyclonet database is also accessible through the BioUML workbench, which allows flexible querying, analyzing and editing the data by means of visual modelling. Cyclonet aims to predict promising anticancer targets and their agents by application of Prediction of Activity Spectra for Substances. The Cyclonet database is available at http://cyclonet.biouml.org.
哺乳动物细胞周期调控的计算建模是一项具有挑战性的任务，它需要对细胞中许多相互关联的过程有全面的了解。我们开发了一个基于网络的综合数据库，用于存储正常和病理状态下哺乳动物细胞周期调控的相关信息（Cyclonet数据库）。该数据库基于系统生物学方法，整合了“组学”科学和化学信息学所获得的数据。Cyclonet是一个专门的资源库，它能使从事抗癌药物研发领域的研究人员以系统的方式分析当前可得的大量信息。Cyclonet包含有关相关基因和分子的信息；细胞周期调控的图表和模型及其模拟结果；关于细胞周期和各类癌症的微阵列数据、药物靶点及其配体的信息，以及关于细胞周期建模和癌症相关基因表达数据的大量参考文献。还可通过BioUML工作台访问Cyclonet数据库，该工作台允许通过可视化建模灵活地查询、分析和编辑数据。Cyclonet旨在通过应用物质活性谱预测来预测有前景的抗癌靶点及其药物。Cyclonet数据库可在http://cyclonet.biouml.org上获取。
