Lok C, Ruto F, Labeille B, Pietri J, Denoeux J P
Service de Dermatologie et Vénéréologie, Hôpital Sud, C.H.R.U., Amiens.
J Mal Vasc. 1991;16(4):381-2.
Werner's syndrome (adult progeria) is a rare autosomal recessive condition characterized mainly by a characteristic habitus (short stature, light body weight) scleroderma like changes of the limbs and premature aging. Chronic leg ulcers appears in about fifty per cent of the patients. These ulcers can be related to the combination of mechanical factors on atrophic subcutaneous tissue and skin of the feet and leg associated with early arteriosclerosis (20%) and diabetes mellitus (60%).
韦纳综合征(成人早老症)是一种罕见的常染色体隐性疾病,主要特征为特殊体型(身材矮小、体重轻)、四肢硬皮病样改变和早衰。约50%的患者会出现慢性腿部溃疡。这些溃疡可能与足部和腿部萎缩性皮下组织及皮肤的机械因素,以及早期动脉硬化(20%)和糖尿病(60%)共同作用有关。