Hürlimann A F, Schnyder U W
Dermatologische Universitätsklinik Zürich.
Hautarzt. 1991 Nov;42(11):721-5.
Werner's syndrome is a rare, autosomal recessive inherited disorder with a distinctive clinical picture. The characteristic physiognomy, shortness of stature with thin extremities, and large trophic ulcers are the key signs for the diagnosis. Premature greying of the hair and baldness, juvenile cataracts, a tendency to diabetes mellitus, hypogonadism, calcifications of the blood vessels, osteoporosis, metastatic calcifications of the soft tissue and an elevated incidence of neoplasms are further important features. We describe two patients with this disorder.
沃纳综合征是一种罕见的常染色体隐性遗传性疾病，具有独特的临床表现。典型的面容、身材矮小且四肢纤细以及巨大的营养性溃疡是诊断的关键体征。头发过早变白和脱发、青少年白内障、糖尿病倾向、性腺功能减退、血管钙化、骨质疏松、软组织转移性钙化以及肿瘤发病率升高是进一步的重要特征。我们描述了两名患有这种疾病的患者。
