局部应用他克莫司在白塞病中向房水的渗透情况。

Penetration of topically applied tacrolimus into the aqueous humor in Behçet's disease.

作者信息

Yalçindağ F Nilüfer, Batioğlu Figen, Ozdemir Ozden

机构信息

Ophthalmology Department, Ankara University Faculty of Medicine, Esat Caddes i 74/3 Küçükesat, Ankara, 06660, Turkey.

出版信息

Ann Ophthalmol (Skokie). 2007 Spring;39(1):15-7. doi: 10.1007/BF02697321.

DOI:10.1007/BF02697321

PMID:17914200

Abstract

We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behçet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0.3% every 6 hours for 3 days. The mean tacrolimus concentration in the aqueous and serum, as measured by microparticle enzyme immunoassay, were 12.49 and 0.76 ng/mL, respectively. Tacrolimus may be a promising treatment modality in anterior uveitis in Behçet's disease by topical application.

摘要

我们对11例眼部白塞病患者局部应用他克莫司后房水和血清中的他克莫司浓度进行了研究。所有患者每6小时接受1滴0.3%的等渗他克莫司溶液，共3天。通过微粒酶免疫测定法测得，房水和血清中他克莫司的平均浓度分别为12.49 ng/mL和0.76 ng/mL。局部应用他克莫司可能是治疗白塞病前葡萄膜炎的一种有前景的治疗方式。