CXC 趋化因子在不同内源性葡萄膜炎临床实体患者房水中的表达谱。
CXC chemokine expression profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.
机构信息
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Immunobiology. 2011 Sep;216(9):1004-9. doi: 10.1016/j.imbio.2011.03.007. Epub 2011 Apr 7.
Aqueous humor (AH) samples from patients with Behçet's disease (BD) (n=29), Vogt-Koyanagi-Harada (VKH) disease (n=21), and HLA-B27-associated uveitis (n=8), and 42 control patients were assayed for the neutrophil chemoattractants CXCL1/GRO-α and CXCL8/IL-8 and the lymphocyte chemoattractants CXCL9/MIG, CXCL10/IP-10 and CXCL12/SDF-1 with the use of a multiplex chemokine assay. Chemokine levels except SDF-1 were significantly higher in the 3 disease groups than in normal controls. Considering all patients, mean GRO-α levels were 15-fold higher than IL-8 levels and mean IP-10 levels were 22-fold higher than MIG levels. In patients with the same disease activity, AH levels of GRO-α and IP-10 were significantly higher in patients with BD than in patients with VKH disease and HLA-B27-associated uveitis (p=0.0474; p<0.001, respectively). These data suggest that GRO-α and IP-10 are the predominant CXC chemokines involved in neutrophil and activated T lymphocyte chemoattraction in endogenous uveitis, particularly in BD.
对 29 例 Behçet 病 (BD)、21 例 Vogt-Koyanagi-Harada (VKH) 病和 8 例 HLA-B27 相关葡萄膜炎患者以及 42 例对照患者的房水 (AH) 样本进行了中性粒细胞趋化因子 CXCL1/GRO-α 和 CXCL8/IL-8 以及淋巴细胞趋化因子 CXCL9/MIG、CXCL10/IP-10 和 CXCL12/SDF-1 的测定，采用了一种多重趋化因子测定法。除了 SDF-1 之外，这 3 种疾病组的趋化因子水平均显著高于正常对照组。考虑到所有患者，GRO-α 水平的平均值是 IL-8 水平的 15 倍，IP-10 水平的平均值是 MIG 水平的 22 倍。在具有相同疾病活动度的患者中，BD 患者的 AH 中 GRO-α 和 IP-10 水平明显高于 VKH 病和 HLA-B27 相关葡萄膜炎患者 (p=0.0474；p<0.001)。这些数据表明，GRO-α 和 IP-10 是参与内源性葡萄膜炎中性粒细胞和活化 T 淋巴细胞趋化的主要 CXC 趋化因子，特别是在 BD 中。
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