Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Immunobiology. 2011 Sep;216(9):1004-9. doi: 10.1016/j.imbio.2011.03.007. Epub 2011 Apr 7.
Aqueous humor (AH) samples from patients with Behçet's disease (BD) (n=29), Vogt-Koyanagi-Harada (VKH) disease (n=21), and HLA-B27-associated uveitis (n=8), and 42 control patients were assayed for the neutrophil chemoattractants CXCL1/GRO-α and CXCL8/IL-8 and the lymphocyte chemoattractants CXCL9/MIG, CXCL10/IP-10 and CXCL12/SDF-1 with the use of a multiplex chemokine assay. Chemokine levels except SDF-1 were significantly higher in the 3 disease groups than in normal controls. Considering all patients, mean GRO-α levels were 15-fold higher than IL-8 levels and mean IP-10 levels were 22-fold higher than MIG levels. In patients with the same disease activity, AH levels of GRO-α and IP-10 were significantly higher in patients with BD than in patients with VKH disease and HLA-B27-associated uveitis (p=0.0474; p<0.001, respectively). These data suggest that GRO-α and IP-10 are the predominant CXC chemokines involved in neutrophil and activated T lymphocyte chemoattraction in endogenous uveitis, particularly in BD.
对 29 例 Behçet 病 (BD)、21 例 Vogt-Koyanagi-Harada (VKH) 病和 8 例 HLA-B27 相关葡萄膜炎患者以及 42 例对照患者的房水 (AH) 样本进行了中性粒细胞趋化因子 CXCL1/GRO-α 和 CXCL8/IL-8 以及淋巴细胞趋化因子 CXCL9/MIG、CXCL10/IP-10 和 CXCL12/SDF-1 的测定，采用了一种多重趋化因子测定法。除了 SDF-1 之外，这 3 种疾病组的趋化因子水平均显著高于正常对照组。考虑到所有患者，GRO-α 水平的平均值是 IL-8 水平的 15 倍，IP-10 水平的平均值是 MIG 水平的 22 倍。在具有相同疾病活动度的患者中，BD 患者的 AH 中 GRO-α 和 IP-10 水平明显高于 VKH 病和 HLA-B27 相关葡萄膜炎患者 (p=0.0474；p<0.001)。这些数据表明，GRO-α 和 IP-10 是参与内源性葡萄膜炎中性粒细胞和活化 T 淋巴细胞趋化的主要 CXC 趋化因子，特别是在 BD 中。
