He Lin, He Xingyue, Lowe Scott W, Hannon Gregory J
Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Nat Rev Cancer. 2007 Nov;7(11):819-22. doi: 10.1038/nrc2232.
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
最近的几项研究发现,一个保守的微小RNA(miRNA)家族,即miR-34s,是p53的直接转录靶点。miR-34的激活可以重现p53活性的一些要素,包括诱导细胞周期停滞和促进细胞凋亡,而miR-34的缺失会损害p53介导的细胞死亡。这些数据进一步强化了人们越来越强烈的认识,即非编码RNA通过使miRNA在一个著名的肿瘤抑制网络中发挥核心作用,从而成为肿瘤发展中的关键因素。