正电子发射断层扫描有助于早发性阿尔茨海默病的诊断。
Positron emission tomography facilitates diagnosis of early-onset Alzheimer's disease.
作者信息
McMurtray Aaron M, Licht Eliot, Yeo Tuty, Krisztal Erica, Saul Ronald E, Mendez Mario F
机构信息
Department of Neurology, University of California at Los Angeles (UCLA), Calif., USA.
出版信息
Eur Neurol. 2008;59(1-2):31-7. doi: 10.1159/000109258. Epub 2007 Oct 4.
BACKGROUND
Clinical positron emission tomography (PET) may help in the evaluation of presenile patients with memory complaints for the presence of Alzheimer's disease (AD).
METHODS
Clinical PET scans from 27 patients with clinically probable AD and early ages of onset (<65 years) were compared to PET scans from 27 age-matched controls presenting with memory complaints, but without dementia or mild cognitive impairment.
RESULTS
Compared to controls, the AD patients had significant frontal, temporal and parietal hypometabolism bilaterally, and AD diagnosis correlated with left temporal and right temporoparietal hypometabolism. The sensitivity of temporoparietal hypometabolism for AD was 92.6%, the specificity 85.2%.
CONCLUSION
Clinical PET imaging helps distinguish early-onset AD from patients with memory complaints not meeting criteria for dementia or mild cognitive impairment.
背景
临床正电子发射断层扫描（PET）可能有助于评估有记忆障碍的早老患者是否患有阿尔茨海默病（AD）。
方法
将27例临床诊断为可能患有AD且发病年龄较早（<65岁）的患者的临床PET扫描结果与27例年龄匹配、有记忆障碍但无痴呆或轻度认知障碍的对照者的PET扫描结果进行比较。
结果
与对照组相比，AD患者双侧额叶、颞叶和顶叶存在明显的代谢减低，AD诊断与左侧颞叶和右侧颞顶叶代谢减低相关。颞顶叶代谢减低对AD的敏感性为92.6%，特异性为85.2%。
结论
临床PET成像有助于将早发型AD与不符合痴呆或轻度认知障碍标准的有记忆障碍的患者区分开来。
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