Little Tanya J, Russo Antonietta, Meyer James H, Horowitz Michael, Smyth Douglas R, Bellon Max, Wishart Judith M, Jones Karen L, Feinle-Bisset Christine
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Gastroenterology. 2007 Oct;133(4):1124-31. doi: 10.1053/j.gastro.2007.06.060. Epub 2007 Jul 3.
BACKGROUND & AIMS: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males.
Nine men (age, 23 +/- 2 y; body mass index, 22 +/- 1 kg/m(2)) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4% milk protein and labeled with 15 MBq (123)I), or (3) 600 mL 4% milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake.
GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 +/- 610 kJ; TG, 5463 +/- 662 kJ; FFA, 4199 +/- 410 kJ).
FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.
脂肪对胃排空（GE）、肠道激素及能量摄入的影响取决于其消化为游离脂肪酸（FFA）的程度。在动物实验中，小肠中的油酸比三酰甘油（TG）三油精更有效地抑制能量摄入，但关于FFA和TG对人类的比较作用的信息有限。我们比较了FFA和TG对健康男性的胃排空、肠道激素分泌、食欲及能量摄入的影响。
9名男性（年龄23±2岁；体重指数22±1kg/m²）分3次接受研究，以评估（1）40g油酸（FFA，1830kJ）、（2）40g澳洲坚果油（TG，1856kJ；两者均为用4%乳蛋白稳定、标记有15MBq（123）I的600mL水包油乳剂）或（3）600mL 4%乳蛋白（对照，352kJ）经胃内给药后对胃排空、血浆胆囊收缩素（CCK）和肽YY（PYY）水平、食欲感知及随后能量摄入的影响。
FFA的胃排空比TG慢得多（P<.05），与TG相比，FFA在胃近端的潴留更多（P<.001）。与对照和TG相比，摄入FFA后饥饿感减轻（P<.05），饱腹感增强（P<.05）。FFA后血浆CCK和PYY水平的升高比TG或对照更大（P<.05）。与TG相比，摄入FFA后能量摄入倾向于减少（对照，4754±610kJ；TG，5463±662kJ；FFA，4199±410kJ）。
在健康人体内，FFA从胃中排空更慢，但比TG更有效地刺激CCK和PYY并抑制食欲。
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