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西酞普兰诱发尖端扭转型室速,这是一种罕见的危及生命的副作用。

Citalopram induced torsade de pointes, a rare life threatening side effect.

作者信息

Kanjanauthai Somsupha, Kanluen Tony, Chareonthaitawee Panithaya

出版信息

Int J Cardiol. 2008 Dec 17;131(1):e33-4. doi: 10.1016/j.ijcard.2007.08.006. Epub 2007 Oct 4.

Abstract

Acquired Long QT syndrome is a disorder caused by medications, electrolyte imbalances, and drug interactions. This syndrome is associated with an increased risk of a characteristic life-threatening cardiac arrhythmia, known as torsade de pointes (TdP). In the setting of Long QT syndrome (LQTS), selective serotonin reuptake inhibitors (SSRIs) can precipitate TdP. We report the first case of LQTS and TdP induced by citalopram in the United States. After discontinuation of citalopram, the QT/QTc interval normalized after 3 days and resolved further episodes of TdP. Patients on citalopram should be monitored closely for QT/QTc interval to prevent torsade de pointes.

摘要

获得性长QT综合征是一种由药物、电解质失衡和药物相互作用引起的疾病。该综合征与一种特征性的危及生命的心律失常——尖端扭转型室速(TdP)的风险增加有关。在长QT综合征(LQTS)的情况下,选择性5-羟色胺再摄取抑制剂(SSRI)可诱发TdP。我们报告了美国首例由西酞普兰诱发的LQTS和TdP病例。停用西酞普兰后,QT/QTc间期在3天后恢复正常,TdP发作也进一步得到缓解。服用西酞普兰的患者应密切监测QT/QTc间期,以预防尖端扭转型室速。

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