Yoshimura H, Kimura N
Central Research Laboratory, Ehime University School of Medicine, Japan.
Neurosci Biobehav Rev. 1991 Winter;15(4):497-500. doi: 10.1016/s0149-7634(05)80138-1.
The present study was designed to investigate how the experience of fighting affects copulatory behavior in male mice and also to determine the effect of naloxone on the interaction between social conflict and copulatory disorder. To generate intraspecific fighting a resident-intruder paradigm was employed. Agonistic confrontations were terminated after 10 or 20 attack bites, and were repeated for 5 consecutive days. Twenty-four hours after the last confrontation test, both resident and intruder mice were tested with estrus females for 10 min. Compared to the control group without agonistic confrontation, intruder mice that had been attacked repeatedly showed a significant reduction of copulatory behavior. In contrast, attacking resident mice showed a significant increase in copulatory behavior. Pretreatment with naloxone (1 and 3 mg/kg, IP) prior to daily fighting failed to antagonize defeat-induced copulatory disorder. It would, therefore, appear that endogenous opioid mechanism may not participate in this phenomenon.
本研究旨在调查争斗经历如何影响雄性小鼠的交配行为，并确定纳洛酮对社会冲突与交配障碍之间相互作用的影响。为引发种内争斗，采用了居住者-入侵者范式。在10次或20次攻击撕咬后终止争斗对抗，并连续重复5天。在最后一次对抗测试24小时后，对居住者和入侵者小鼠与处于发情期的雌性交配10分钟进行测试。与未经历争斗对抗的对照组相比，反复受到攻击的入侵者小鼠的交配行为显著减少。相反，实施攻击的居住者小鼠的交配行为显著增加。在每日争斗前用纳洛酮（1和3毫克/千克，腹腔注射）预处理未能拮抗失败诱导的交配障碍。因此，内源性阿片类机制似乎可能不参与此现象。
