Kantak K M, Miczek K A
Psychopharmacology (Berl). 1986;90(4):451-6. doi: 10.1007/BF00174059.
Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience. In naive mice, removal of a morphine pellet led to increases in attack bites and threats but naloxone-precipitated withdrawal led to decreases in these behaviors and to increases in defensive posturing, escape attempts and vocalizations. Prior fighting experience abolished the enhanced attack behaviors of resident mice following morphine pellet removal, but led to heightened defensive behavior in intruder mice. The behavior of intruder mice appeared more sensitive to naloxone administration than the behavior of resident mice; naloxone influenced not only intruder defensive behavior, but also other non-aggressive behaviors. The social role of the drug recipient and his prior history of aggressive behavior are important determinants of morphine and naloxone effects on aggression.
在定居小鼠和入侵小鼠中确定攻击行为的进攻和防御成分。在未接触过吗啡的小鼠皮下注射吗啡丸剂移除后或用纳洛酮诱发戒断后，以及在有过战斗经验的小鼠移除吗啡丸剂后，测量退缩性攻击行为。在未接触过吗啡的小鼠中，移除吗啡丸剂会导致攻击撕咬和威胁行为增加，但纳洛酮诱发的戒断会导致这些行为减少，并导致防御姿态、逃跑尝试和发声增加。先前的战斗经验消除了定居小鼠在移除吗啡丸剂后增强的攻击行为，但导致入侵小鼠的防御行为增强。入侵小鼠的行为似乎比定居小鼠的行为对纳洛酮给药更敏感；纳洛酮不仅影响入侵小鼠的防御行为，还影响其他非攻击性行为。药物接受者的社会角色及其先前的攻击行为史是吗啡和纳洛酮对攻击行为影响的重要决定因素。
