Mitchell P J, Fletcher A, Redfern P H
Wyeth Research (UK) Ltd., Maidenhead, Berkshire, England.
Neurosci Biobehav Rev. 1991 Winter;15(4):539-44. doi: 10.1016/s0149-7634(05)80145-9.
Remission from depressive illness is associated with a modification in patients' behavioural reactions to environmental/social stimulation, and requires continuous drug treatment. We have examined the effects of antidepressant drug treatment and repeated electroconvulsive shock (ECS) on the behaviour of rats during social interaction (SI) to determine whether antidepressant treatments modify behavioural patterns of experimental animals that may be related to their ability to modify reactive human behaviour. Acute treatment of short-term isolated resident rats with nonsedative doses of antidepressant drugs, or sedative doses of haloperidol and diazepam, dose relatedly reduced aggressive behaviour exhibited during SI. Conversely, chronic antidepressant treatment (including ECS), but not chronic haloperidol or diazepam treatment, increased the aggressive behaviour of resident rats. These studies have revealed selective, diametrically opposite, effects of acute and chronic antidepressant treatment on rodent aggressive behaviour that may be indicative of antidepressant efficacy. The effects of chronic antidepressant treatment in particular may indicate a disinhibition of rodent social behaviour which may mirror the externalisation of emotions associated with the remission of depressive illness.
抑郁症的缓解与患者对环境/社会刺激的行为反应改变有关，且需要持续的药物治疗。我们研究了抗抑郁药物治疗和重复电休克（ECS）对大鼠社交互动（SI）行为的影响，以确定抗抑郁治疗是否会改变实验动物的行为模式，而这些行为模式可能与其改变人类反应性行为的能力有关。用非镇静剂量的抗抑郁药物、或镇静剂量的氟哌啶醇和地西泮对短期隔离的独居大鼠进行急性治疗，剂量相关地减少了SI期间表现出的攻击行为。相反，慢性抗抑郁治疗（包括ECS），但不是慢性氟哌啶醇或地西泮治疗，增加了独居大鼠的攻击行为。这些研究揭示了急性和慢性抗抑郁治疗对啮齿动物攻击行为的选择性、截然相反的影响，这可能表明抗抑郁疗效。特别是慢性抗抑郁治疗的效果可能表明啮齿动物社会行为的去抑制，这可能反映了与抑郁症缓解相关的情绪外化。
