ADAM和ADAMTS金属蛋白酶在癌症中的新作用。

Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.

作者信息

Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gueders M, Foidart J M, Noel A, Cataldo D

机构信息

Department of Biology of Tumours and Development, GIGA-Research (Groupe Interdisciplinaire de Génoprotéomique Appliquée) and Center for Experimental Cancer Research (CECR), University of Liege and CHU of Liège, Liege, Belgium.

出版信息

Biochimie. 2008 Feb;90(2):369-79. doi: 10.1016/j.biochi.2007.08.008. Epub 2007 Sep 2.

DOI:10.1016/j.biochi.2007.08.008

PMID:17920749

Abstract

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural features distinguish the membrane-anchored ADAMs and the secreted ADAMs with thrombospondin motifs referred to as ADAMTSs. By acting on a large panel of membrane-associated and extracellular substrates, they control several cell functions such as adhesion, fusion, migration and proliferation. The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions.

摘要

解整合素金属蛋白酶（ADAMs）是最近发现的一类蛋白质家族，它们与基质金属蛋白酶（MMPs）共享金属蛋白酶结构域。在这个家族中，结构特征区分了膜锚定的ADAMs和具有血小板反应蛋白基序的分泌型ADAMs，后者被称为ADAMTSs。通过作用于大量膜相关和细胞外底物，它们控制多种细胞功能，如黏附、融合、迁移和增殖。本综述主要探讨了这些蛋白酶在癌症进展的正负调控中的作用，其主要通过生长因子活性和整合素功能的调节来介导。