[APOA5基因多态性与中国人群血脂水平及动脉粥样硬化性脑梗死的相关性]
[Association of APOA5 gene polymorphism with levels of lipids and atherosclerotic cerebral infarction in Chinese].
作者信息
Li Jie, Xu Hong-wei, Zhu Xiao-yan
机构信息
Department of Emergency, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Oct;24(5):576-8.
OBJECTIVE
To investigate the relationship between the polymorphism of apolipoprotein A5 gene (APOA5) -12238 T>C and atherosclerotic cerebral infarction (ACI).
METHODS
Three hundred and forty-one subjects (170 ACI patients and 171 healthy controls) were collected to determine the genotypes by using polymerase chain reaction-restriction fragment length polymorphisms.
RESULTS
APOA5 allele frequencies of T/C were 0.588/0.412 and 0.424/0.576 in ACI group and control group respectively. There was significant difference in allele and genotype frequencies between ACI group and control group (P < 0.05). The levels of plasma triglyceride in ACI patients with TT genotype were higher than those in patients with CC genotypes (P < 0.05).
CONCLUSION
The relationship is found between the site of APOA5 gene -12238 T>C and ACI. There is a significant correlation between TT genotype of APOA5 and the levels of plasma triglyceride in patients with ACI.
目的
探讨载脂蛋白A5基因（APOA5）-12238T>C多态性与动脉粥样硬化性脑梗死（ACI）之间的关系。
方法
收集341例受试者（170例ACI患者和171例健康对照），采用聚合酶链反应-限制性片段长度多态性方法确定基因型。
结果
ACI组和对照组中APOA5基因T/C等位基因频率分别为0.588/0.412和0.424/0.576。ACI组与对照组之间的等位基因和基因型频率存在显著差异（P<0.05）。TT基因型的ACI患者血浆甘油三酯水平高于CC基因型患者（P<0.05）。
结论
发现APOA5基因-12238T>C位点与ACI之间存在关联。APOA5基因的TT基因型与ACI患者血浆甘油三酯水平之间存在显著相关性。
Zotero 插件