Swigut Tomek, Wysocka Joanna
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cell. 2007 Oct 5;131(1):29-32. doi: 10.1016/j.cell.2007.09.026.
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.
多梳复合体（PRC2）蛋白对组蛋白H3上赖氨酸27位点（H3K27me）的甲基化与许多发育过程中的基因沉默有关。最近的一系列论文（阿格等，2007年；德·桑塔等，2007年；兰等，2007年；李等，2007年）将含有JmjC结构域的蛋白UTX和JMJD3鉴定为H3K27特异性去甲基化酶，它们能去除这种甲基标记，从而激活参与动物身体模式形成和炎症反应的基因。
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