Bachelot A, Laborde K, Bresson J L, Plu-Bureau G, Raynaud A, Bertagna X, Mogenet A, Mansour M, Lucas-Jouy V, Gayno J-P, Reznik Y, Kuhn J-M, Billaud L, Vacher-Lavenu M-C, Putterman M, Mowszowicz I, Touraine P, Kuttenn F
Endocrinology, Pitié-Salpétrière Hospital, 83 boulevard de l'Hôpital, 75013, Paris, France.
J Endocrinol Invest. 2007 Sep;30(8):636-46. doi: 10.1007/BF03347443.
Hyperandrogenism and ovulatory dysfunction are common in women with either polycystic ovary (PCOS) or ovarian virilizing tumor. However, contrasting with the numerous studies that have extensively described gonadotropin secretory abnormalities, principally increased LH pulse amplitude and frequency, few studies have concerned gonadotropin secretion in patients with ovarian virilizing tumors; low gonadotropin levels have occasionally been reported, but never extensively studied. The goal of the present study was to further evaluate the pulsatility of LH secretion in women with ovarian virilizing tumor compared with that of PCOS patients. Eighteen women with major hyperandrogenism (plasma testosterone level >1.2 ng/ml) were studied (5 women with ovarian virilizing tumor, 13 women with PCOS, and 10 control women). Mean plasma LH level, LH pulse number and amplitude were dramatically low in patients with ovarian tumors when compared to both PCOS (p<0.001) and controls (p<0.001). In case of major hyperandrogenism, LH pulse pattern differs markedly between women with ovarian virilizing tumor or PCOS, suggesting different mechanisms of hypothalamic or pituitary feedback.
高雄激素血症和排卵功能障碍在患有多囊卵巢（PCOS）或卵巢男性化肿瘤的女性中很常见。然而，与大量广泛描述促性腺激素分泌异常（主要是LH脉冲幅度和频率增加）的研究形成对比的是，很少有研究关注卵巢男性化肿瘤患者的促性腺激素分泌；偶尔有低促性腺激素水平的报道，但从未进行过广泛研究。本研究的目的是进一步评估与PCOS患者相比，卵巢男性化肿瘤女性LH分泌的脉冲性。对18名高雄激素血症（血浆睾酮水平>1.2 ng/ml）的女性进行了研究（5名患有卵巢男性化肿瘤的女性、13名PCOS女性和10名对照女性）。与PCOS患者（p<0.001）和对照者（p<0.001）相比，卵巢肿瘤患者的平均血浆LH水平、LH脉冲数和幅度显著降低。在高雄激素血症的情况下，患有卵巢男性化肿瘤或PCOS的女性之间的LH脉冲模式明显不同，提示下丘脑或垂体反馈机制不同。
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