Murphy W M
Acta Cytol. 1976 May-Jun;20(3):207-10.
A case of squamous cell carcinoma of the urinary bladder in which herpesvirus virions could be identified by electron microscopy is presented. The value of cytology in the recognition of the typical intranuclear inclusions which led to the initiation of further studies is emphasized. Recent evidence concerning the relationship between herpesviruses and human cancer is briefly reviewed. Although previous reports have emphasized the association of HSV and uterine cervical carcinoma, other combinations, especially with neoplasms of squamous cell type, have been reported. The accumulation of additional cases in which viruses can be demonstrated in cancers will help to define their role in human neoplasia.
本文报告一例膀胱鳞状细胞癌，通过电子显微镜可识别出疱疹病毒颗粒。强调了细胞学在识别典型核内包涵体方面的价值，正是这种包涵体引发了进一步的研究。简要回顾了有关疱疹病毒与人类癌症关系的最新证据。尽管先前的报告强调了单纯疱疹病毒（HSV）与子宫颈癌的关联，但也有其他组合的报道，特别是与鳞状细胞类型肿瘤的组合。积累更多能在癌症中证明存在病毒的病例，将有助于明确它们在人类肿瘤形成中的作用。
