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[儿童后颅窝髓母细胞瘤/原始神经外胚层肿瘤治疗的现代进展]

[Modern aspects of treatment of medulloblastomas/primitive neuroectodermal tumors of the posterior cranial fossa in children].

作者信息

Nagulić M, Popović V, Golubicić I

机构信息

Neurosurgical University Hospital, UCC, Belgrade.

出版信息

Srp Arh Celok Lek. 1991 Jul-Aug;119(7-8):190-3.

PMID:1792575
Abstract

The authors present 34 medulloblastoma/primitive neuroectodermal tumours of the posterior fossa in children operated during the last ten years (1979-1989). Total removal of tumours has been performed in 13, and maximal-subtotal resection in 19 patients. Only four tumours were classified as small (group T1-T2). Partial reduction and biopsy were possible in four cases. The average period from surgery to the beginning of radio-oncologic treatment was 31 days. Radio- and chemotherapy were applied according to international standards. Permanent cerebrospinal fluid derivation preceded surgery in 9 patients (VA shunt in 6 and VP in 3) and after surgery of the posterior fossa in four children. Early postsurgical mortality rate, related to the first five years of this study, was 5.6%. Seven children (20.6%) survived from five to ten years after operation. The authors are advocating for standardization of diagnostical and surgical procedures, and for unification of postoperative control with intention to obtain longer duration of survival of these seriously sick children.

摘要

作者介绍了过去十年(1979 - 1989年)间接受手术治疗的34例儿童后颅窝髓母细胞瘤/原始神经外胚层肿瘤。13例患者实现了肿瘤全切,19例患者进行了次全切除。仅4例肿瘤被归类为小型(T1 - T2组)。4例患者可行部分肿瘤缩减及活检。从手术到开始放化疗的平均时间为31天。放化疗按照国际标准进行。9例患者(6例行脑室-腹腔分流术,3例行脑室-胸腔分流术)在手术前行永久性脑脊液引流,4例儿童在后颅窝手术后行脑脊液引流。与本研究的前五年相关的早期术后死亡率为5.6%。7例儿童(20.6%)术后存活5至10年。作者主张诊断和手术程序的标准化,以及术后监测的统一,以期延长这些重病儿童的生存期。

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