Li Na, Wang Yu-rong, Zhong Ai-mei, Wang Wen-juan
Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong, University of Science and Technology, Wuhan 430022, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2007 Jul;23(4):324-7.
To investigate the expression and significance of CD133, Glut-1 and precursor cell, placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.
We examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.
The expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).
The precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.
探讨CD133、葡萄糖转运蛋白1（Glut-1）及前体细胞、胎盘微血管内皮细胞在婴幼儿血管瘤发生、发展及消退过程中的表达及意义。
采用免疫组织化学技术检测CD133、Glut-1在婴幼儿血管瘤及先天性血管畸形出生后血管畸形发生、发展及消退过程中的表达及意义。应用图像分析系统（Image-pro plus 5.0）测量血管瘤不同阶段及血管畸形中CD133和Glut-1的平均积分光密度及阳性面积率。
先天性血管瘤、先天性血管畸形、胎盘绒毛膜中CD133的表达明显高于出生后血管畸形（P<0.05）。关于Glut-1的表达，增殖期血管瘤、胎盘与消退期血管瘤、血管畸形之间存在差异（P<0.05）。
标记为CD133的前体细胞是先天性血管瘤和先天性血管畸形来源的内皮细胞的来源。
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