Huang Wei, Hu Xiao-Li, Gao Xin-Feng, Liu Yi, Zhao Lin-Sheng
Department of Plastic Surgery, Tianjin Children' s Hospital, Tianjin 300074, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2009 Sep;25(5):321-4.
To investigate the development, distribution and GLUT-1 expression of infantile hemangioma and to discuss the early surgical intervention for better results and avoiding severe complication.
The lesion site of each case was recorded and analyzed by SPSS V13.0 to study the distribution. The operation was guided by the principle of plastic surgery to remove the hemangioma. The GLUT-1 expression was detected by immunohistochemical technique in all the resected samples.
All the results were satisfactory. The GLUT-1 expression was positive in all the cases. The incidences in different sites were significantly different (P < 0.05). 71.7% of the hemangiomas were located at upper and lower lip, periorbital region and facial midline. It indicates that hemangioma is not randomly distributed. Most of them were located at the fusion of facial prominences during embryological development.
Infantile facial hemangioma maybe originated from endothelial progenitor cells of placenta which migrate and implant on the fusion of facial prominences. Early surgical intervention is one of the best choice for infantile facial hemangioma.
研究婴幼儿血管瘤的发生、分布及葡萄糖转运蛋白1（GLUT-1）的表达情况，探讨早期手术干预以获得更好疗效并避免严重并发症。
应用SPSS V13.0软件记录并分析各病例的病变部位以研究其分布情况。手术遵循整形外科学原则切除血管瘤。采用免疫组化技术检测所有切除标本中GLUT-1的表达。
所有结果均令人满意。所有病例中GLUT-1表达均为阳性。不同部位的发病率差异有统计学意义（P<0.05）。71.7%的血管瘤位于上下唇、眶周区域及面部中线。这表明血管瘤并非随机分布。大多数血管瘤位于胚胎发育过程中面部突起的融合部位。
婴幼儿面部血管瘤可能起源于胎盘的内皮祖细胞，这些细胞迁移并种植于面部突起的融合部位。早期手术干预是婴幼儿面部血管瘤的最佳选择之一。
